I've used one for NRA High Power for about four years at 200, 300, and 600 yards. It is extremely accurate in my Tubb 2000 rifle.
Barrel life is not as good as a .223 or .308 in general. Velocity is lower than a .243. Most of the dope on it talks about how to get high velocity with 107 or 115 grain bullets. For 200 yards I use a reasonably light load of H4350 with 70 grain SMKs which is said to develop only about 40,000 psi. I have also used 85 grain varmint bullets and they are as accurate as SMKs. For 600 yards I use 107 grain SMKs and also use H4350.
I have used Norma cases and fire-formed 22-250 cases. With my light loads, I have one box of 44 (20 offhand, 20 sitting rapid, and two sighters for each stage) 22-250 cases which has been loaded 25 times so far with no apparent problems.
That said, for 200 or 300 yards, I don't think it has any advantage over a .223.
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