That's not really a comparison at all. I would certainly hope there would be different results between 12ga and .410. Where TSS comes into play, in my opinion, is in the sub-gauges, as has been said all along. Without TSS, I wouldn't use a .410, while in a 12 gauge, it would be completely optional. TSS is a game changer and available if you want to use it and feel it's worth it. Take a look at the TSS threads in the reloading forum, people are getting some incredible results with it.