I shot a 10 point at 170 yards a few years ago with a 308 150gr NBT. If I didn't see him fall a 100 yards away, I would have thought I missed, no blood and he didn't do nothing but run with his tail up.
My cousin's wife dropped a 10 point this year with her 223 AR, 55gr V-max didn't even wiggle.

As stick says, it's all about the bullet. But I'll add, and where you place that bullet.