Ramshot Big Game works great with 286's. Usually around 63-65 grains will get 2400+ and fine accuracy. Charlie Sisk and I pressure-tested this load with Nosler Partitions and it is safe. My own CZ 550 gets 2475 with this load and it really does the job on about anything.

The 286 Partition, by the way, has the partition further forward than most Noslers, so retains at least 85% of its weight and usually more like 90%. It will really penetrate.

MD