I have both (8mm & 3006)and if you are not a handloader then 3006 is the way to go. I used my 8x57 this year to kill a nice 6 point at 190 yards. Handloaded they are the same as far as what they can kill. If you are a handloader then I would suggest a 25-06 the fill your gap. I was thinking about getting a savage 243 to fill the gap in my gun case. or if I can find a nice 257 bob I will go with that. M8x57